Donald Trump's successful campaign to oust Louisiana Sen. Bill Cassidy in a GOP primary — payback for Cassidy's 2021 vote to convict Trump following his second impeachment — is drawing sharp criticism as a strategically self-destructive move. Cassidy, one of seven Republican senators who voted to convict, tried to rehabilitate himself by swallowing his misgivings and voting to confirm RFK Jr. as HHS Secretary. It wasn't enough. Trump never forgave him, and Louisiana Gov. Jeff Landry helped seal Cassidy's fate by engineering a switch from open to closed partisan primaries, stripping Cassidy of the independent and Democratic support that had long bolstered him.
The seat itself is likely safe — Trump-endorsed Rep. Julia Letlow faces state treasurer John Fleming in a runoff, and either is favored in reliably red Louisiana. But the broader pattern of Trump's retribution politics is putting Senate Republican control at genuine risk. Trump's approval rating sits at just 40.1% in the RealClearPolitics average, a level that historically endangers congressional majorities.
The casualty list is mounting. Trump drove North Carolina Sen. Thom Tillis into retirement, and Democrats now hold the edge there. Trump has targeted Maine's Susan Collins — calling for her to never hold office again over a war powers vote — potentially suppressing GOP turnout in a state already difficult for Republicans. MAGA pressure is also linked to Iowa Sen. Joni Ernst's retirement, turning a previously safe seat into a possible Democratic pickup as farmers suffer under tariffs and inflation. And Trump's refusal to endorse Texas Sen. John Cornyn despite direct appeals from Majority Leader John Thune and campaign chair Tim Scott opens the door to a primary win by AG Ken Paxton — who could then lose to Democrat James Talarico.
If Republicans lose all of those competitive seats, the GOP could fall to 49 senators. A Democratic Senate would end Trump's ability to confirm conservative judges and expose him to relentless oversight investigations in his final two years. A Democratic House takeover would kill his legislative agenda entirely. Trump has dominated GOP fundraising since his reelection — but he may need to spend heavily just to avoid finishing his presidency as, in the bluntest terms, a lame duck.
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